Neeltje Steeghs

M.D., Ph.D., Licensed Medical Oncologist and Clinical Pharmacologist and Head of Early Drug Development Center & Head of Clinical Research Unit

Neeltje Steeghs served as chair of the Dutch Pharmacology Oncology Group and chair of the Dutch GIST consortium. Her main scientific interests are new drug development, including the performance of clinical phase I and early phase II trials, and the inclusion of pharmacokinetics and pharmacodynamics in these studies. She also has a major interest in the design aspects of early clinical studies.

Besides her clinical activities, she has been Clinical Assessor for the Medicines Evaluation Board of the European Medicines Agency (2009-2011), chairman of the Dutch Sarcoma Study Group, board member for the Paediatric Oncology Research Foundation (2010-2013), Young investigator for the EORTC Soft Tissue and Bone Sarcoma Group (2013-2016), chairman of the multidisciplinary expert board for the Center for Personalized Cancer Treatment (2012-2015) and Vice-Chairman of the Medical Ethical Committee of the Netherlands Cancer Institute. She has also been board member for the Dutch Oncological Medicine Evaluation Board, the National Working Party for Cancer Drugs Interactions and the Translational Research Board of the Netherlands Cancer Institute. She has been editor of Gastrointestinal Stromal Tumor (GIST), Frontiers in Oncology; Pharmacology of Anti-Cancer Drugs and guest editor for Cancers.She currently serves as the Director of Phase I studies and Clinical Research at the Netherlands Cancer Institute, in Amsterdam, the Netherlands and as advisor for several pharmaceutical companies.

Neeltje Steeghs has been principal investigator for many investigator initiated and industry sponsored clinical trials. She is regarded as a leading authority on mechanisms for safe and effective dosing of anticancer agents. She has authored or co-authored over 150 scientific papers, and has given numerous lectures on a variety of topics at international meetings.

Specialism and interests

  • Early Drug Development and Clinical Trials
  • Targeted Therapy
  • Personalized Dosing
  • Trials Designs and Dosing Strategies
  • Investigator Initiated Studies with pharmacological concepts
  • GIST, sarcoma

Publications

Find a list of Neeltje Steeghs' publications here.

Relevant committees/networks/other relevant to mention

  • Board member of Early Phase Clinical Trials Group of Cancer Core Europe
  • Member of Methodology for the Development of Innovative Cancer Therapies
    (MDICT) group. In 2022: Identifying the optimal dose - practical issues and
    recommendations for the conduct and design of phase I studies
  • Chair of the Dutch vPharmacology Oncology Group
  • Chair of the Dutch GIST consortium.
  • Vice-Chair of the Medical Ethical Committee of the Netherlands Cancer Institute.
  • Board member for the Dutch Oncological Medicine Evaluation Board Board member of the National Working Party for Cancer Drugs Interactions
  • Board member of the Translational Research Board of the Netherlands Cancer Institute
  • Editor of Gastrointestinal Stromal Tumor (GIST), Frontiers in Oncology; Pharmacology of Anti-Cancer Drugs and guest editor for Cancers
  • Clinical Assessor for the Medicines Evaluation Board of the European Medicines Agency
    (2009-2011)
  • Past chair of the Dutch Sarcoma Study Group
  • Past Board member for the Paediatric Oncology Research Foundation (2010-2013)
  • Past Young investigator for the EORTC Soft Tissue and Bone Sarcoma Group (2013-2016),
  • Past chair of the multidisciplinary expert board for the Center for Personalized Cancer Treatment (2012-2015)